“Normal” Labs but Still Exhausted? Mitochondrial Series (Pt 1): Mitophagy + 4-Step Protocol

“Normal” Labs but Still Exhausted? Mitochondrial Series (Pt 1): Mitophagy + 4-Step Protocol

Hillary Lin, MD

By 

Hillary Lin, MD

Published 

December 30, 2025

If you’re sleeping well, eating clean, exercising—and still exhausted—this may be an engine problem, not a fuel problem.

This is Part 1 of my Mitochondrial Health Series, where I start with the foundation: mitophagy—your body’s ability to clear damaged mitochondria.

In longevity medicine, I call this mitophagy failure: damaged mitochondria (“zombie batteries”) stop producing clean energy and leak signals that can trigger inflammation, brain fog, and that 2 p.m. crash.

In this video, I break down:

• Why zombie mitochondria can keep you stuck in “sickness behavior”

• The key biology: PINK1 + Parkin (how your cells tag and remove broken mitochondria)

• My 4-step energy protocol: 14–16 hr overnight fasting, Zone 2 cardio, heat (sauna/hot bath), and urolithin A + spermidine

• The NAD+ trap: why NMN/NR can backfire if you “fuel” before you “clean”

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